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BlueGene Biotech P01G0016P Human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Protein, Recombinant

  • Metabolism

Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) can also be called CSF2.

Products

Specifications Of P01G0016P Human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Protein, Recombinant

Product Information

catalog number

P01G0016P

Package Size

10ug/50ug/500ug/1mg

Other Names

CSF2

Protein & NCBI Number

M11220, P04141

Host

E.coli 

Express Region

Ala18-Glu144

Protein Sequence

APARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTC
LQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKE
NLKDFLLVIPFDCWEPVQE

Molecular Weight

The protein consists of 127 amino acids (including the fusion tag), with a predicted
molecular weight of 14.5kDa. Due to glycosylation, and the actual molecular weight is 11kDa.

Fusion Tag

None

Purity

≥95% SDS-PAGE

Physical Property

Liquid

Components

0.01M PBS+20% glycerol, sterile solution.

Storage & Stability

After aliquoting, the stability of the samples can be maintained for up to 6 months at
 -20°C to -80°C, avoiding repeated freeze-thaw cycles.

Applications

Antibody preparation, immunoassay (ELISA, WB), subcellular localization and interaction protein identification, etc.

Lead Time

5 to 10 business days; 

2 to 3 days for stock products


Background

Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), also known as Colony-Stimulating Factor 2 (CSF2), is a monomeric glycoprotein. Unlike Granulocyte
Colony-Stimulating Factor (G-CSF), which specifically promotes the proliferation and maturation of neutrophils, GM-CSF affects a broader range of cell types,
particularly macrophages and eosinophils.

High levels of GM-CSF have been detected in the joints of patients with rheumatoid arthritis, and targeting GM-CSF as a biological target can reduce inflammation or
tissue damage. In critically ill patients, GM-CSF has been trialed as an immunosuppressive therapy, showing potential in restoring the function of monocytes and
neutrophils.

The functions of GM-CSF include: Hematopoiesis and differentiation of bone marrow lineage cells; Development and maintenance of alveolar macrophages; 

Recruitment and differentiation of monocyte-derived dendritic cells (DCs), including the production of IL-23 and polarization of TH17 T cells; Maturation and antigen
presentation by conventional DCs, such as CD103-expressing DCs in the skin and small intestine; Polarization of M1 macrophages, including the production of
pro-inflammatory cytokines, phagocytosis, and antigen presentation; Priming and activation of neutrophils, including processes such as phagocytosis, oxidative
bursts, and nitric oxide generation.


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