Human Interleukin 4 (IL 4) can also be called as BSF1, IL-4, BCGF1, BSF-1, BCGF-1.
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Specifications Of P01I0069 Human IL 4 Protein, Recombinant
BSF1; IL-4; BCGF1; BSF-1; BCGF-1
Protein & NCBI Number
Total length of the protein（including Tag）
liquid or lyophilized powder
Storage solution: We recommend using PBS or a suitable solvent according to the experimental requirements to prepare 1mg/mL storage solution, aliquot and store at -20 °C.
Working solution: According to the experimental requirement, dilute Storage solution. The working solution can be stored at 4°C for 2-3 weeks after dilution.
Storage & Stability
The shelf life of liquid form is 6 months stored at -20 °C /-80 °C.
The shelf life of lyophilized form is 12 months stored at -20 °C /-80 °C.
Antibody preparation, immunoassay (ELISA, WB), subcellular localization and interaction protein identification, etc.
5 to 10 business days;
2 to 3 days for stock products
IL-4 is a pleiotropic cytokine produced by activated T cells. It undergoes N glycosylation sites and different degrees of glycosylation under different conditions. The precursor of IL-4 is 153 peptide, and the mature IL-4 is 129 peptide after removing the signal peptide.The biological effects of IL-4 are mediated by binding to the IL-4 receptor (IL-4R).The Interleukin 4 receptor also binds to IL13, which may result in many overlapping functions of this cytokine and IL-13.STAT6 is a signal transduction and transcriptional activator that has been shown to play a central role in mediating immunomodulatory signaling of this cytokine.
IL-4 is considered to be an important cytokine for tissue repair, counteracting the effects of type 1 proinflammatory cytokines; however, it also promotes allergic airway inflammation.In addition, IL-4, as a characteristic cytokine of Th2 cells, plays a role in promoting the occurrence and development of inflammatory responses characterized by Th2, mediating and regulating a variety of human host responses, such as allergy, anti-parasite, wound healing, and acute inflammation.Il-4 significantly upregates THE CXC chemokine receptor on THE surface of CD4+T cells to mediate the inflammatory response, which may be mediated by cAMP or cGMP signal transduction pathways.
IL-4 has been reported to promote the regression of neutrophil-mediated acute lung injury.In allergic reactions, IL-4 plays an important role in the production of allergen-specific immunoglobulin IgE. An increase in this pro-inflammatory cytokine has been observed in PATIENTS with COVID-19, but is not necessarily associated with severe COVID-19 pathology.Two variable-splice transcripts of this gene encoding different isoforms have been reported.