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BlueGene Biotech P01I0053 Human Interleukin 1β (IL 1β) Protein, Recombinant

Interleukin 1β (IL 1β) can also be called as IL-1, IL1F2, IL1beta, IL1-BETA.

Specifications Of P01I0053 Human IL 1β Protein, Recombinant

Porduct's Information Porduct's Information

CatalogNumber

P01I0053

Package Size

10ug/50ug/100ug/1mg

Other Names

IL-1; IL1F2; IL1beta; IL1-BETA

Protein & NCBI Number

P01584, NM_000576.3

Host

E.coli

Express Region

1-269aa

Protein Length

Total length of the protein(including Tag)

Protein Sequence

MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS

Molecular Weight

about30.7kDa

Fusion Tag

6×His-SUMO (N-terminus)

Purity

≥95% SDS-PAGE

PhysicalProperty

liquid or lyophilized powder

Reconstitution

Storage solution: We recommend using PBS or a suitable solvent according to the experimental requirements to prepare 1mg/mL storage solution, aliquot and store at -20 °C.

Working solution: According to the experimental requirement, dilute Storage solution. The working solution can be stored at 4°C for 2-3 weeks after dilution.

Storage & Stability

The shelf life of liquid form is 6 months stored at -20 °C /-80 °C.

The shelf life of lyophilized form is 12 months stored at -20 °C /-80 °C.

Applications

Antibody preparation, immunoassay (ELISA, WB), subcellular localization and interaction protein identification, etc.

Lead Time

5 to 10 business days;

2 to 3 days for stock products



Background

Interleukin IL-1β also known as catabolin, is a member of the interleukin 1 cytokine family. IL1B, the cytokine encoded by the IL1B gene, is an inflammatory response and fever mediator, and contributes to several lymphocyte activities including growth and differentiation of B-cells, proliferation of T-helper Type2 (Th2) clones, and activation of Th17 cells. IL-1β is produced in peripheral blood mononuclear cells, tissue macrophages, and dendritic fine cells in response to immune responses, inflammation, infection, and trauma cells such as cytium. IL1B is required for T-cell activation in some immune responses, and thus could contribute to increased T-cell replication. IL-1β can also act on distant target cells in an endocrine manner to induce systemic immune response. IL-1β can rapidly induce the expression of cytokines such as IL-6 and IL-8 of various cell types. At the same time, IL-1β also induces its own expression, forming a positive feedback loop and amplifying the IL-1 response.


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