Name: P03I0308P-T1 Mouse Interleukin 2 (IL2) Protein, Recombinant
Brand: Shanghai BlueGene Biotech CO., LTD.
Price: 100 USD

BlueGene Biotech P03I0308P-T1 Mouse Interleukin 2 (IL2) Protein, Recombinant

Immunology

Neuroscience

Cancer

Metabolism

Interleukin 2 (IL2) can also be called IL-2; TCGF; lymphokine.

Products

Specifications of P03I0308P-T1 Mouse Interleukin 2 (IL2) Protein, Recombinant

Product Information
catalog number	P03I0308P-T1
Package Size	10ug/50ug/500ug/1mg
Other Names	IL-2; TCGF; lymphokine
Protein & NCBI Number	P04351
Host	E.coli
Express Region	Met1-Gln169
Protein Sequence	MYSMQLASCVTLTLVLLVNSAPTSSSTSSSTAEAQQQQQQQQQQQQHLEQLLMDLQ ELLSRMENYRNLKLPRMLTFKFYLPKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLE DAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFCQSIISTSPQ
Molecular Weight	The protein consists of 303 amino acids (including the fusion tag), with a predicted molecular weight of 34.4kDa, which matches the actual molecular weight
Fusion Tag	SUMO(N-terminus), (6×His (C-terminus)
Purity	≥60% SDS-PAGE
Physical Property	Liquid
Components	0.01M PBS+20% glycerol, sterile solution
Storage & Stability	After aliquoting, the stability of the samples can be maintained for up to 6 months at -20°C to -80°C, avoiding repeated freeze-thaw cycles
Applications	Applications Antibody preparation, immunoassay (ELISA, WB), subcellular localization and interaction protein identification, etc
Lead Time	5 to 10 business days; 2 to 3 days for stock products

Background

Interleukin-2 (IL-2) exerts both immunosuppressive and immunostimulatory effects on cytotoxic effector cells by activating regulatory T cells (Tregs). These IL-2-mediated effects depend on distinct expression patterns of IL-2 receptors (IL-2R): CD8+T cells and natural killer (NK) cells express high levels of the dimeric IL-2Rβ(CD122) and IL-2Rγ(γc) chains, while Treg cells express high levels of IL-2Rα(CD25) along with intermediate levels of CD122 and γc.

IL-2 was the first cytokine to be molecularly cloned and is an essential T cell growth factor, required for T cell proliferation, effector cell generation, and memory cell development. IL-2 supports the development, survival, and functional activity of Treg cells, thereby exerting dual and opposing roles: maintain Treg cells to suppress immune responses while activating conventional T cells to promote immune responses..

Studies have demonstrated that certain IL-2 conformations preferentially target Treg cells by increasing dependency on CD25 binding while reducing interaction with CD122. Recent therapeutic strategies have emerged that utilize IL-2, IL-2 monoclonal antibodies, or IL-2 variants to enhance the number and function of Treg cell for the treatment of autoimmune diseases, while simultaneously addressing the ongoing challenge of minimizing the activation of effector T cells, memory T cells, NK cells, and other innate lymphoid cell populations.