Name: P01I0007P-T2 Human Interleukin 4 (IL-4) Protein, Recombinant
Brand: Shanghai BlueGene Biotech CO., LTD.
Price: 100 USD

BlueGene Biotech P01I0007P-T2 Human Interleukin 4 (IL-4) Protein, Recombinant

Immunology

Cardiovascular

Interleukin 4 (IL-4) can also be called BSF1; IL-4; BCGF1; BSF-1; BCGF-1.

Products

Specifications Of P01I0007P-T2 Human Interleukin 4 (IL-4) Protein, Recombinant

Product Information
catalog number	P01I0007P-T2
Package Size	10ug/50ug/500ug/1mg
Other Names	BSF1; IL-4; BCGF1; BSF-1; BCGF-1
Protein & NCBI Number	P05112, NM_000589.4
Host	E.coli
Express Region	Met1-Ser153
Protein Sequence	MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKET FCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS
Molecular Weight	The protein consists of 153 amino acids (including the fusion tag), with a predicted molecular weight of 31.8kDa, which matches the actual molecular weight.
Fusion Tag	6×His-SUMO (N-terminus)
Purity	≥90% SDS-PAGE
Physical Property	Liquid
Components	0.01M PBS+20% glycerol, sterile solution
Storage & Stability	After aliquoting, the stability of the samples can be maintained for up to 6 months at -20°C to -80°C, avoiding repeated freeze-thaw cycles.
Applications	Antibody preparation, immunoassay (ELISA, WB), subcellular localization and interaction protein identification, etc.
Lead Time	5 to 10 business days; 2 to 3 days for stock products

Background

IL-4 is a pleiotropic cytokine produced by activated T cells. It undergoes N glycosylation sites and different degrees of glycosylation under different conditions. The precursor of IL-4 is 153 peptide, and the mature IL-4 is 129 peptide after removing the signal peptide.The biological effects of IL-4 are mediated by binding to the IL-4 receptor (IL-4R).
The Interleukin 4 receptor also binds to IL13, which may result in many overlapping functions of this cytokine and IL-13.STAT6 is a signal transduction and transcriptional
activator that has been shown to play a central role in mediating immunomodulatory signaling of this cytokine.

IL-4 is considered to be an important cytokine for tissue repair, counteracting the effects of type 1 proinflammatory cytokines; however, it also promotes allergic airway
inflammation.In addition, IL-4, as a characteristic cytokine of Th2 cells, plays a role in promoting the occurrence and development of inflammatory responses characterized
by Th2, mediating and regulating a variety of human host responses, such as allergy, anti-parasite, wound healing, and acute inflammation.Il-4 significantly upregates THE
CXC chemokine receptor on THE surface of CD4+T cells to mediate the inflammatory response, which may be mediated by cAMP or cGMP signal transduction pathways.

IL-4 has been reported to promote the regression of neutrophil-mediated acute lung injury.In allergic reactions, IL-4 plays an important role in the production of
allergen-specific immunoglobulin IgE. An increase in this pro-inflammatory cytokine has been observed in PATIENTS with COVID-19, but is not necessarily associated with
severe COVID-19 pathology.Two variable-splice transcripts of this gene encoding different isoforms have been reported.