Human Transforming Growth Factor-beta3 (TGFB3) can also be called TGFB3, ARVD, TGF-beta3.
Specifications of P01T0168P-T2 Human Transforming Growth Factor-beta3 (TGFB3), Recombinant
| Product Information | |
catalog number | P01T0168P-T2 |
Package Size | 10ug/50ug/500ug/1mg |
Other Names | TGFB3, ARVD, TGF-beta3 |
Protein & NCBI Number | P10600 |
Host | E.coli |
Express Region | Ala301-Ser412 |
Protein Sequence | ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS |
Molecular Weight | The protein consists of 234 amino acids, with a predicted molecular weight of 26.6kDa, which matches the actual molecular weight. |
Fusion Tag | 6×His-SUMO (N-terminus) |
Purity | ≥90% SDS-PAGE |
Physical Property | Liquid |
Components | 20 mM Tris-HCl+ 150 mM NaCl+10% glycerol,pH 8.0 sterile solution. |
Storage & Stability | After aliquoting, the stability of the samples can be maintained for up to 6 months at -20°C to -80°C, avoiding repeated freeze-thaw cycles. |
Applications | Antibody preparation, immunoassay (ELISA, WB), subcellular localization, identification of interacting proteins, etc. |
Lead Time | 5 to 10 business days; 2 to 3 days for stock products |
Background |
Transforming growth factor-beta3 (TGFB3) is a human protein encoded by the TGFB3 gene. As a cytokine, this protein participates in cell differentiation, embryogenesis and organismal development. It belongs to the large transforming growth factor- beta superfamily, which comprises multiple cytokines including the TGF-beta family, bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), inhibins and activins. Studies have demonstrated that TGFB3 regulates molecules related to cell adhesion and extracellular matrix (ECM) formation during palatal development. Loss of TGFB3 in mammals results in cleft palate malformation, caused by the failure of epithelial cells on both sides of the embryonic palate to fuse properly. Furthermore, TGFB3 plays an essential role in mammalian lung development by modulating cell adhesion and extracellular matrix synthesis in lung tissues. Meanwhile, it regulates epidermal and dermal cell migration in injured skin and participates in wound healing processes. |
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