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BlueGene Biotech P01B0012 Human Bone Morphogenetic Protein Receptor Type 1B (BMPR1B) Protein, Recombinant

Bone Morphogenetic Protein Receptortype 1B (BMPR1B) can also be called as ALK-6, ALK6, AMD3, AMDD, BDA1D, BDA2, CDw293.

Specifications Of P01B0012 Human BMPR1B Protein, Recombinant

Porduct's Information

CatalogNumber

P01B0012

Package Size

10ug/50ug/100ug/1mg

Other Names

ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2; CDw293

Protein & NCBI Number

O00238, NM_001256793.2

Host

E.coli

Express Region

1-532aa

Protein Length

Total length of the protein(including Tag)

Protein Sequence

MGWLEELNWQLHIFLLILLSMHTRANFLDNMLLRSAGKLNVGTK

KEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCL

GLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLI

SVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGS

GSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETE

IYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKL

AYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTN

EVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV

EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNP

ASRLTALRVKKTLAKMSESQDIKL

Molecular Weight

about 60.6kDa

Fusion Tag

6×His-SUMO (N-terminus)

Purity

≥95% SDS-PAGE

PhysicalProperty

liquid or lyophilized powder

Reconstitution

Storage solution: We recommend using PBS or a suitable solvent according to the experimental requirements to prepare 1mg/mL storage solution, aliquot and store at -20 °C.

Working solution: According to the experimental requirement, dilute Storage solution. The working solution can be stored at 4°C for 2-3 weeks after dilution.

Storage & Stability

The shelf life of liquid form is 6 months stored at -20 °C /-80 °C.

The shelf life of lyophilized form is 12 months stored at -20 °C /-80 °C.

Applications

Antibody preparation, immunoassay (ELISA, WB), subcellular localization and interaction protein identification, etc.

Lead Time

5 to 10 business days;

2 to 3 days for stock products



Background

BMPR1B gene,a member of the bone morphogenetic protein (BMP) receptor family,encodes transmembrane serine/threonine kinases,and binds BMPs. BMPs are members of the TGF-beta superfamily and involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors:

type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Several transcript variants encoding two different isoforms have been found for this gene.

BMPR1A and BMPR1B have overlapping functions. BMPR1A and BMPR1B are expressed during early chondrogenesis in mice and are necessary for chondrogenesis in vivo and crucial for endochondral ossification. Recent studies suggest that stronger BMPR1B signaling, compared with BMPR1A signaling, prevents chondrocyte hypertrophy and acts as a cartilage stabilizer during joint morphogenesis.


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